MMDN - Production scientifique

Akbaraly T, Miot S , Baghdadli A (2019) Nutritional Epidemiology Research in the Field of Autism Spectrum Disorders–A Review. Neuropsychiatry (in press)

Akbaraly TN, Singh-Manoux A, Dugravot A, Brunner EJ, Kivimaki M, Sabia S (2019) Association of Midlife Diet With Subsequent Risk for Dementia. Jama 321:957-968.

Arribat Y, Mysiak KS, Lescouzères L, Boizot A, Ruiz M, Rossel M, Bomont P (2019) Mutations in the Gigaxonin-E3 ligase impede the initiation of Shh signaling to cause Giant Axonal Neuropathy. J Clin Invest (in press)

Baghdadli A, Miot S, Rattaz C, Akbaraly TN, Geoffray M-M, Michelon C, Loubersac J, Traver S, Mortamais M, Sonié S, Pottelette J, Robel L, Speranza M, Vesperini S, Maffre T, Falissard B, Picot M-C (2019) Investigating the natural history and prognostic factors of ASD in children: the multicEntric Longitudinal study of childrEN with ASD - the ELENA study protocol. BMJ Open 9: e026286

Brodoline A, Rawat N, Alexandre D, Cubedo N, Gross M (2019) 4D compressive sensing holographic imaging of small moving objects with multiple illuminations. Applied Optics 58: G127-G134.

Brodoline A, Rawat N, Alexandre D, Cubedo N, Gross M (2019) 4D compressive sensing holographic imaging of small moving objects. Optics Letters 44, 2827.

Chudinova A, Rossel M, Vergunst AC, Le Masson G, Camu W, Raoul C, Lumbroso S, Mouzat K (2019) Theme 4 In vivo experimental models. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20: 160–187

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze J-F, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen L-P, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine J-M, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM (2019) A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun 10: 3669

Canet G, Hernandez C, Zussy C, Chevallier N, Desrumaux C,Givalois L(2019) Is AD a stress-related disorder? Focus on the HPA axis and its promising therapeutic targets.Frontiers in Aging Neuroscience 11:269.

Ghazale H, Ripoll C, Leventoux N, Jacob J, Azar S, Mamaeva D, Glasson Y , Calvo CF, Thomas JL, Meneceur S, Lallemand Y, Rigau V, Perrin FE, Noristani HN, Rocamonde B, Huillard E, Bauchet L, Hugnot JP (2019). RNA profiling of the human and mouse spinal cord stem cell niches reveals an embryonic-like dorsal-ventral regionalization with MSX1+ roof-plate-derived cells. Stem Cell Reports, (in press).

Filip S, Mokrý J, Forostyak O, Dayanithi G (2019) Analysis of Ca2+ signaling mechanisms - our experience on the intercellular communication in muscle remodeling. Physiol Res. (In press).

Filip S, Mokrý J, Forostyak O, Dayanithi G (2019) The extracellular matrix and Ca2+ signaling mechanisms. Physiol Res. (in press).

Folio DM, Aars J, Gimenez O, Derocher AE, Wiig Ø, Cubaynes S (2019) How many cubs can a mum nurse? Maternal age and size influence litter size in polar bears. Biol. Lett. 15: 20190070

Gunesch S, Kiermeier C, Hoffmann M, Fischer W, Pinto A, Maurice T, Maher P, Decker M (2019) 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory in vivo. Redox Biol (in press)

Haydar S, Grigorescu F, Vintilă M, Cogne Y, Lautier C, Tutuncu Y, Brun JF, Robine JM, Pugeat M, Normand C, Poucheret P, Gheorghiu ML, Georgescu C, Badiu C, Băculescu N, Renard E, Ylli D, Badiou S, Sutra T, Cristol JP, Mercier J, Gomis R, Macias JM, Litvinov S, Khusnutdinova E, Poiana C, Pasquali R, Lauro D, Sesti G, Prudente S, Trischitta V, Tsatsoulis A, Abdelhak S, Barakat A, Zenati A, Ylli A, Satman I, Kanninen T, Rinato Y, Missoni S (2019) Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation. PLoS ONE 14: e0214122

Hoffmann M, Stiller C, Endres E, Scheiner M, Gunesch S, Sotriffer C, Maurice T, Decker M (2019) Tunable duration of action of highly selective BChE inhibitors by chemical modification of transferable carbamate moieties lead to pronounced neuroprotective effects in an Alzheimer´s disease mouse model. J Med Chem 62: 9116-9140.

Kayano T, Sasaki Y, Kitamura N, Harayama N, Moriya T, Dayanithi G, Verkhratsky A, Shibuya I (2019) Persistent Na+ influx drives L-type channel resting Ca2+ entry in rat melanotrophs. Cell Calcium 79:11-19.

Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Sillman I, Sussman J, Weik M, Maurice T, Dallemagne P, Rochais C (2019) Synthesis, evaluation and structural characterization of novel multitarget directed ligand targeting acetylcholinesterase and sigma-1 receptors of potential interest for Alzheimer's disease treatment. Eur J Med Chem 162: 234-248.

LarouiN, CubedoN, Rossel M, Bettache N (2019) Improvement of cell penetrating peptide for efficient siRNA targeting of tumor xenografted in zebrafish embryos. Advanced Therapeutics (in press).

Lasbleiz C, Mestre-Francés N, Devau G, Luquin MR, Tenenbaum L, Kremer EJ, Verdier JM (2019) Combining gene transfer and nonhuman primates to better understand and treat Parkinson’s disease. Front Mol Neurosci.12:10

Lassale C, Batty GD, Baghdadli A, Jacka F, Sánchez-Villegas A, Kivimaki M, Akbaraly TN, Batty GD (2019) Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Molecular Psychiatry 24: 965–986

Lassale C, Batty GD, Steptoe A, Cadar D, Akbaraly TN, Kivimaki M, Zaninotto P (2019) Association of 10-Year C-Reactive Protein Trajectories With Markers of Healthy Aging: Findings From the English Longitudinal Study of Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 74:195-203.

Lepvrier E, Thomas D, Garnier C (2019) Hsp90 Quaternary Structures and the Chaperone Cycle: Highly Flexible Dimeric and Oligomeric Structures and Their Regulation by Co-Chaperones. Current Proteomics 16: 5–11

Manzo E, Lorenzini I, Barrameda D, O'Conner AG, Barrows JM, Starr A, Kovalik T, Rabichow BE, Lehmkuhl EM, Shreiner DD, Joardar A, Liévens JC, Bowser R, Sattler R, Zarnescu DC. (2019) Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS. Elife8 : e45114.

Marelli C, Salsano E, Politi LS, Labauge P (2019) Spinal cord involvement in adult-onset metabolic and genetic diseases. Journal of Neurology, Neurosurgery and Psychiatry 90: 211–218

Maurice T, Volle JN, Strehaiano M, Crouzier L, Pereira C, Kaloyanov N, Virieux D, Pirat JL (2019) Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer's disease by positive modulation of σ1 receptors. Pharmacol Res 144: 315-330.

Noristani HN, Perrin FE (2019). Use of longitudinal magnetic resonance imaging in preclinical models of spinal cord injury. Editorial Neural Regeneration Research, 14: 771-772.

Nusselder WJ, Cambois E, Wapperom D, Meslé F, Looman C, Yokota RTC, Van Oyen H, Jagger C, Robine J-M (2019) Women’s excess unhealthy life years: disentangling the unhealthy life years gap. European Journal of Public Health 29: 914-919

Pagnamenta AT, Heemeryck P, Martin HC, Bosc C, Peris L, Uszynski I, Gory-Fauré S, Couly S, Deshpande C, Siddiqui A, Elmonairy AA, Jayawant S, Murthy S, Walker I, Loong L, Bauer P, Vossier F, Denarier E, Maurice T, Barbier EL, Deloulme JC, Taylor JC, Blair EM, Andrieux A, Moutin MJ (2019) Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice. Hum Mol Genet (in press).

Rama R, Garzón F, Rodríguez Cruz Y, Maurice T, García Rodríguez JC (2019) Neuroprotective effect of NeuroEPO in neurodegenerative disease: “Alea jacta est”. Neural Regener Res 14: 1519-1521.

Recchia D, Baghdadli A, Lassale C, Brunner E, Verdier JM, Kivimaki M, Akbaraly (2019). Associations between long-term adherence to healthy diet and recurrent depressive symptoms in Whitehall II Study. European journal of nutrition (in press)

Scheiner M, Gunesch S, Dolles D, Hoffmann M, Oliviero M, Nabissi M, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Maurice T, Decker M (2019) Dual-acting cholinesterase-human cannabinoid receptor 2 ligands show pronounced neuroprotection in vitro, and overadditive and disease-modifying neuroprotective effects in vivo. J Med Chem. 62: 9078-9102.

Torrent J, Martin D, Igel-Egalon A, Beringue VV and Rezaei H (2019) High-Pressure Response of Amyloid Folds. Viruses 11: pii: E202

Trousse F, Jemli A, Silhol M, Garrido E, Crouzier L, Naert G, Maurice T, Rossel M (2019) Knockdown of CXCL12 /CXCR7 chemokine pathway results in learning deficits and neural progenitors maturation failure in mice. Brain Behav Immun. 80: 697-710.

Vavers E, Zvejniece L, Maurice T, Dambrova M (2019) Allosteric modulators of sigma-1 receptor: a review. Front Pharmacol 10: 223.

Zub E, Canet G, Garbelli R, Blaquiere M,Rossini L, Pastori C, Sheikh M, Reutelingsperger C, Klement W, de Bock F, Audinat E, Givalois L, Solito E, MarchiN (2019) The ANXA1-GR pathway is a pathological player and a potential pharmacological target in epilepsy. FASEB Journal 33:13998-14009

Barbereau C, Yehya A, Silhol M, Cubedo N, Verdier JM, Maurice T,Rossel M (2020) Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacological Research 158:104865.

Canet G, Pineau F, Zussy C, Hernandez C, Hunt H, Chevallier N, Perrier V, Torrent J, Belanoff JK, Meijer OC, Desrumaux C, Givalois L (2020) Glucocorticoid receptors signaling impairment potentiates amyloid-β oligomers-induced pathology in an acute model of Alzheimer’s disease. The FASEB Journal 34:1150–1168

Couly S, Khalil B, Viguier V, Roussel J, Maurice T, Liévens JC (2020) Sigma-1 receptor is a key modulator in amyotrophic lateral sclerosis. Hum Mol Genet 29:529-540

Delprat B, Crouzier L, Su TP, Maurice T (2020) At the Crossing of ER Stress and MAMs: A Key Role of Sigma-1 Receptor? Adv Exp Med Biol 1131:699-718

Dibakou SE, Souza A, Boundenga L, Givalois L, Mercier-Delarue S, Simon F, Prugnolle F, Huchard E, Charpentier MJ (2020) Ecological, parasitological and individual determinants of plasma neopterin levels in a natural mandrill population. Int J Parasitol Parasites Wildl 11:198-206

Fritz R, Zimmermann E, Picq J, Lautier C, Meier M, Kästner S, Schmidtke D (2020) Sex-specific patterns of age-related cerebral atrophy in a non-human primate Microcebus murinus. Neurobiology of Aging (in press)

Lafon PA, Wang Y, Arango-Lievano M, Torrent J, Salvador-Prince L, Mansuy M, Mestre-Francès N, Givalois L, Liu J, Mercader JV, Jeanneteau F, Desrumaux C, Perrier V (2020) Fungicide residues exposure and β-amyloid aggregation in a mouse model of Alzheimer's disease. Environ Health Perspect 128:17011

Lee PT, Liévens JC, Wang SM, Chuang JY, Khalil B, Wu HE, Chang WC, Maurice T, Su TP (2020) Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models. Nat Commun 11:5580

Liévens JC, Maurice T(2020) Sigma-1 receptor: Culprit and rescuer in motor neuron diseases. Neural Regeneration Research (in press)

Paschon V, Fernandes Correia F, Cintra Morena B, Allisson da Silva V, Bispo dos Santos G, Carlan da Silva MC, Fogaça Cristante A, Willerth SF, Perrin FE, Hiroaki Kihara (2020). CRISPR, prime editing, optogenetics and DREADDs: new therapeutic approaches provided by emerging technologies in the treatment of spinal cord injury. Mol Neurobiol 57:2085-2100

Puighermanal E, Castell L, Esteve-Codina A, Melser S, Kaganovsky K, Zussy C, Boubaker-Vitre J, Gut M, Rialle S, Kellendonk C, Sanz E, Quintana A, Marsicano G, Martin M, Rubinstein M, Girault JA, Ding JB, Valjent E (2020) Nat Commun 11: 1957

Schmidtke D, Zimmermann E, Trouche S, Fontès P, Verdier JM, Mestre-Francés N (2020) Linking cognition to age and amyloid-ß burden in the brain of a non-human primate (Microcebus murinus). Neurobiology of Aging (in press)

Varilh M, Acquatella-Tran Van Ba I, Silhol M, Nieto-Lopez F, Moussaed M, Lebart MC, Bovolenta P, Verdier JM, Rossel M, Marcilhac A, Trousse F (2020). Reg-1α promotes differentiation of cortical progenitors via its N-terminal active domain. Front Cell Dev Biol, 8:681

Abatematteo FS, Mosier PD, Niso M, Brunetti L, Berardi F, Loiodice F, Contino M, Delprat B, Maurice T, Laghezza A, Abate C. Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect. Eur J Med Chem. 2021 Dec 3;228:114038.

Barbereau C, Cubedo N, Maurice T, Rossel M. Zebrafish models to study new pathways in tauopathies. Int J Mol Sci. 2021;22:4626.

Bassani S, van Beelen E, Rossel M, Voisin N, Morgan A, Arribat Y, Chatron N, Chrast J, Cocca M, Delprat B, Faletra F, Giannuzzi G, Guex N, Machavoine R, Pradervand S, Smits JJ, van de Kamp JM, Ziegler A, Amati F, Marlin S, Kremer H, Locher H, Maurice T, Gasparini P, Girotto G, Reymond A. Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss. Hum Mol Genet. 2021 Sep 15;30(19):1785-1796.

Canouï-Poitrine F, Rachas A, Thomas M, Carcaillon-Bentata L, Fontaine R, Gavazzi G, Laurent M, Robine JM. Magnitude, change over time, demographic characteristics and geographic distribution of excess deaths among nursing home residents during the first wave of COVID-19 in France: a nationwide cohort study. Age Aging. 2021;in press.

Cahu M, Ali LMA, Sene S, Long J, Camerel F, Ciancone M, Salles F, Chopineau J, Devoisselle JM, Felix G, Cubedo N, Rossel M, Guari Y, Bettache N, Larionova J, Gary-Bobo M. A rational study of the influence of Mn2+-insertion in Prussian blue nanoparticles on their photothermal properties. J Mater Chem B. 2021 Dec 8;9(47):9670-9683.

Cecon E, Lhomme T, Maurice T, Luka M, Chen M, Silva A, Wauman J, Zabeau L, Tavernier J, Prévot V, Dam J, Jockers R. Amyloid Beta Peptide Is an Endogenous Negative Allosteric Modulator of Leptin Receptor. Neuroendocrinology. 2021;111(4):370-387.

Chevreau R, Ghazale H, Ripoll C, Chalfouh C, Delarue Q, Hemonnot-Girard AL, Mamaeva D, Hirbec H, Rothhut B, Wahane S, Perrin FE, Noristani HN, Guerout N, Hugnot JP. RNA profiling of mouse ependymal cells after spinal cord injury identifies the oncostatin pathway as a potential key regulator of spinal cord stem cell fate. Cells. 2021 Nov 27;10(12):3332.

Couly S, Carles A, Denus M, Benigno-Anton L, Maschat F, Maurice T. Exposure of R6/2 mice in an enriched environment augments P42 therapy efficacy on Huntington's disease progression. Neuropharmacology. 2021 Mar 15;186:108467. doi: 10.1016/j.neuropharm.2021.108467

Couly S, Denus M, Bouchet M, Rubinstenn G, Maurice T. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157.

Crouzier L, Denus M, Richard EM, Tavernier A, Diez C, Cubedo N, Maurice T, Delprat B. Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish. Int J Mol Sci. 2021 Oct 13;22(20):11049.

Crouzier L, Richard EM, Sourbron J, Lagae L, Maurice T, Delprat B. Use of zebrafish models to boost research in rare genetic diseases. Int J Mol Sci. 2021 Dec 12; 22:13356.

Crouzier L, Diez C, Richard EM, Cubedo N, Barbereau C, Rossel M, Delaunay T, Maurice T, Delprat B. Loss of Pde6a induces rod outer segment shrinkage and visual alterations in pde6a^Q70X mutant zebrafish, a relevant model of retinal dystrophy. Front Cell Dev Biol. 2021

Forner-Piquer I, Klement W, Gangarossa G, Zub E, de Bock F, Blaquiere M, Maurice T, Audinat E, Faucherre A, Lasserre F, Ellero-Simatos S, Gamet-Payrastre L, Jopling C, Marchi N. Varying modalities of perinatal exposure to a pesticide cocktail elicit neurological adaptations in mice and zebrafish. Environ Pollut. 2021 Jun 1;278:116755.

Garcia J, Torres C, Barbieri M., Cambois E, Camarda CG, Caporali A, Meslé F, Poniakina S, Robine JM. Differences in COVID-19 Mortality: the implications of imperfect and diverse data collection systems. Population-E. 2021;76(1):035−072.

Gautier T, Deckert V, Nguyen M, Desrumaux C, Masson D, Lagrost L. New therapeutic horizons for plasma phospholipid transfer protein (PLTP): Targeting endotoxemia, infection and sepsis. Pharmacol Ther. 2021 Dec 30;236:108105.

He F, Chou CJ, Scheiner M, Poeta E, Yuan Chen N, Gunesch S, Hoffmann M, Sotriffer C, Monti B, Maurice T, Decker M. Melatonin- and ferulic acid-based HDAC6 selective inhibitors exhibit pronounced immunomodulatory effects in vitro and neuroprotective effects in a pharmacological Alzheimer's disease mouse model. J Med Chem. 2021 Apr 8;64(7):3794-3812.

Hemonnot-Girard AL, Valverde AJ, Hua J, Delaygue C, Linck N, Maurice T, Rassendren F, Hirbec H. Analysis of CX3CR1 haplodeficiency in male and female APPswe/PSEN1dE9 mice along Alzheimer disease progression. Brain Behav Immun. 2021 Jan;91:404-417.

Jamoussi Y, Zaiter T, Desrumaux C, Acar N, Pellequer Y, Béduneau A. Investigation of the spontaneous nanoemulsification process with medium- and long-chain triglycerides. Colloids Surf B Biointerfaces. 2021 Jan;197:111432.

Lattard A, Poulen G, Bartolami S, Gerber YN, Perrin FE. Negative impact of Sigma-1 receptor agonist treatment on tissue integrity and motor function following spinal cord injury. Front Neuroanat Neuropharmacol. 2021, 12:614949.

Legrand A, Pujol C, Durand CM, Mesnil A, Rubera I, Duranton C, Zuily S, Sousa AB, Renaud M, Boucher JL, Pietrancosta N, Adham S, Orssaud C, Marelli C, Casali C, Ziccardi L, Villain N, Ewenczyk C, Durr A, Mignot C, Stevanin G, Billon C, Hureaux M, Jeunemaitre X, Goizet C, Albuisson J. Pseudoxanthoma elasticum overlaps hereditary spastic paraplegia type 56. J Intern Med. 2021 May;289(5):709-725.

Lievens JC, Maurice T. Sigma-1 receptor: culprit and rescuer in motor neuron diseases. Neural Regen Res. 2021 Jan;16(1):106-107.

Maurice T. Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders. Expert Opin Drug Discov. 2021 Apr;16(4):373-389.

Montaut S, Diedhiou N, Fahrer P, Marelli C, Lhermitte B, Robelin L, Vincent MC, Corti L, Taieb G, Gebus O, Rudolf G, Tarabeux J, Dondaine N, Canuet M, Almeras M, Benkirane M, Larrieu L, Chanson JB, Nadaj-Pakleza A, Echaniz-Laguna A, Cauquil C, Lannes B, Chelly J, Anheim M, Puccio H, Tranchant C. Biallelic RFC1-expansion in a French multicentric sporadic ataxia cohort. J Neurol. 2021 Mar 5.

Moutin E, Sakkaki S, Compan V, Bouquier N, Giona F, Areias J, Goyet E, Hemonnot-Girard AL, Seube V, Glasson B, Benac N, Chastagnier Y, Raynaud F, Audinat E, Groc L, Maurice T, Sala C, Verpelli C, Perroy J. Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice. Mol Psychiatry. 2021

Nakanishi Y, Tsugihashi Y, Akahane M, Noda T, Nishioka Y, Myojin T, Kubo S, Higashino T, Okuda N, Robine JM, Imamura T. Comparison of Japanese Centenarians' and Noncentenarians' Medical Expenditures in the Last Year of Life. JAMA Netw Open. 2021 Nov 1;4(11):e2131884.

Nasri A, Mezni A, Lafon PA, Wahbi A, Cubedo N, Clair P, Harrath AH, Beyrem H, Rossel M, Perrier V. Ethinylestradiol (EE2) residues from birth control pills impair nervous system development and swimming behavior of zebrafish larvae. Sci Total Environ. 2021 May 20;770:145272.

Patergnani S, Marchi S, Delprat B, Wieckowski MR. Editorial: Organelles Relationships and Interactions: A Cancer Perspective. Front Cell Dev Biol. 2021 Apr 8;9:678307.

Perez JCP, Gerber YN, Perrin FE (2021).Dynamic diversity of glial response among species in spinal cord injury. Front Aging Neurosci, in press.

Poulen G, Aloy A, Bringuier C, Mestre-Francés N, Artus E, Cardoso M, Perez JC, Goze-Bac C, Lonjon N, Boukhaddaoui H, Gerber YN, Perrin FE. Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates Theranostics 2021, 11: 8640-59.

Poulen G, Bartolami S, Noristani HN, Perrin FE, Gerber YN. Unlike brief inhibition of microglia proliferation after spinal cord injury, long-term treatment does not improve motor recovery. Brain Sci. 2021 Dec 13;11(12):1643.

Poulen G, Gerber YN, Perez JC, Oubarrahou M, Lonjon N , Vachiery-Lahaye F, Boukhaddaoui H, Perrin F. Coherent anti-stokes Raman scattering microscopy: a label free method to compare spinal cord myelin in different species.Front Phys, 9:6656650.

Quijal-Zamorano M, Martinez-Solanas E, Achebak H, Petrova D, Robine JM, Herrmann FR, Rod. X, Ballester J. Seasonality reversal of temperature attributable mortality projections due to previously unobserved extreme heat in Europe. Lancet Planet Health. 2021 Sep;5(9):e573-e575.

Ravel JM, Benkirane M, Calmels N, Marelli C, Ory-Magne F, Ewenczyk C, Halleb Y, Tison F, Lecocq C, Pische G, Casenave P, Chaussenot A, Frismand S, Tyvaert L, Larrieu L, Pointaux M, Drouot N, Bossenmeyer-Pourié C, Oussalah A, Guéant JL, Leheup B, Bonnet C, Anheim M, Tranchant C, Lambert L, Chelly J, Koenig M, Renaud M. Expanding the clinical spectrum of STIP1 homology and U-box containing protein 1-associated ataxia. J Neurol. 2021 May;268(5):1927-1937.

Scheiner M, Hoffmann M, He F, Poeta E, Chatonnet A, Monti B, Maurice T, Decker M. Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model. J Med Chem. 2021 Jul 8;64(13):9302-9320.

Verkhratsky A, Dayanithi G. When day meets night: Subsiding calcium signalling translates daylight into new neurones. Cell Calcium. 2021 May;95:102385.

Wang Y, Lafon PA, Salvador-Prince L, Gines AR, Trousse F, Torrent J, Prevostel C, Crozet C, Liu J, Perrier V. Prenatal exposure to low doses of fungicides corrupts neurogenesis in neonates. Environ Res. 2021 Apr;195:110829.

Abatematteo FS, Mosier PD, Niso M, Brunetti L, Berardi F, Loiodice F, Contino M, Delprat B, Maurice T, Laghezza A, Abate C. Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 receptor ligands with potent anti-amnesic effect. Eur J Med Chem 2022, 228, 114038.

Ayrignac X, Carra-Dallière C, Codjia P, Mouzat K, Castelnovo G, Ellie E, Etcharry-Bouyx F, Belliard S, Marelli C, Portet F, Le Ber I, Durand-Dubief F, Mathey G, Stankoff B, Dorboz I, Drunat S, Boespflug-Tanguy O, Menjot de Champfleur N, Lumbroso S, Mochel F, Labauge P. Evaluation of CSF1R-related adult onset leukoencephalopathy with axonal spheroids and pigmented glia diagnostic criteria. Eur J Neurol. 2022, 29, 329-334.

Bauchet L, Poulen G, Lonjon N, Vachiery-Lahaye F, Bourinet E, Perrin FE, Hugnot JP. Isolation and culture of precursor cells from the adult human spinal cord. Methods Mol Biol. 2022;2389:103-110.

Benkirane M, Da Cunha D, Marelli C, Larrieu L, Renaud M, Varilh J, Pointaux, M, Baux D, Ardouin O, Vangoethem C, Taulan M, Daumas Duport B, Bergougnoux A, Corbillé AG, Cossé M, Juntas Morales R, Tuffery-Giraud S, Koenig M, Isidor B, Vincent MC. RFC1 nonsense and frameshift variants cause CANVAS: clues for an unsolved pathophysiology. Brain 2022, 145, 3770-3775.

Canet G, Zub E, Zussy C, Hernandez C, Blaquiere M, Garcia V, Vitalis M, deBock F, Moreno-Montano M, Audinat E, Desrumaux C, Planel E, Givalois L*, Marchi N*. Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways. Epilepsia 2022 Apr;63(4):919-935.

Canet G, Zussy C, Hernandez C, Chevallier N, Marchi N, Desrumaux C, Givalois L. Chronic glucocorticoids consumption triggers and worsens experimental Alzheimer's disease-like pathology by detrimental immune-modulations. Neuroendocrinology 2022, 112, 982-997.

Caporali A, Garcia J, Couppié É, Poniakina S, Barbieri M, Bonnet F, Camarda CG, Cambois E, Hourani I, Korotkova D, Meslé F, Penina O, Robine JM, Sauerberg M, Torres C. The demography of COVID-19 deaths database, a gateway to well-documented international data. Sci Data. 2022 Mar 22;9(1):93.

Carles A, Schlernitzauer A, Vignes M, Cros G, Magous R, Maurice T, Oiry C. Heptafluoroisobutyronitrile (C₄F₇N), a gas used for insulating and arc quenching in electrical switchgear, is neurotoxic in the mouse brain. Toxicology. 2022, 480, 153319.

Crouzier L, Danese A, Yasui Y, Richard EM, Liévens JC, Patergnani S, Couly S, Diez C, Denus M, Cubedo N, Rossel M, Thiry M, Su TP, Pinton P, Maurice T, Delprat B. Activation of the sigma-1 receptor chaperone alleviates disorders of Wolfram syndrome by restoring ER-mitochondrion signaling. Science Transl Med 2022, 14, 631.

Crouzier L, Richard EM, Diez C, Alzaeem H, Denus M, Cubedo N, Delaunay T, Glendenning E, Baxendale S, Liévens JC, Whitfield TT, Maurice T, Delprat B. Morphological, behavioral and cellular analyses revealed different phenotype in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Hum Mol Genet. 2022, 31, 2711-2727.

Crouzier L, Richard EM, Diez C, Denus M, Peyrel A, Alzaeem H, Cubedo N, Delaunay T, Maurice T, Delprat B. NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome. Mol Therapy, 2022, 27, 295-308.

Hofmann J, Spatz P, Walther R, Gutmann M, Maurice T, Decker M. Synthesis and biological evaluation of flavonoid-cinnamic acid amide hybrids with distinct activity against neurodegeneration in vitro and in vivo. Chem Eur J. 2022, 28, e202200786.

Lasbleiz C, Peyrel A, Tarot P, Sarniguet J, Crouzier L, Cubedo N, Delprat B, Rossel M, Maurice T, Liévens JC. Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biol 2022, 58, 102542.

Lebart MC, Trousse F, Valette G, Torrent J, Denus M, Mestre-Frances N, Marcilhac A. Reg-1α, a New Substrate of Calpain-2 Depending on Its Glycosylation Status. Int J Mol Sci 2022, 23, 8591.

Marcilhac A. Environnement et Vieillissement, partenaires ou adversaires ?” Éditions UGA 2022

Marelli C, Fouilhoux A, Benoist JF, De Lonlay P, Guffon-Fouilhoux N, Brassier A, Cano A, Chabrol B, Pennisi A, Schiff M, Acquaviva C, Murphy E, Servais A, Lachmann R. Very long-term outcomes in 23 patients with cblA type methylmalonic acidemia. J Inherit Metab Dis 2022, 45, 937-951.

Martin P, Maurice T, Gammaitoni A, Farfel G, Boyd B, Galer B. Fenfluramine modulates the anti-amnesic effects induced by sigma-1 receptor agonists and neuro(active)steroids in vivo. Epilepsy Behav, 2022, 127,108526.

Nasri A, Lafon PA, Mezni A, Clair P, Cubedo N, Mahmoudi E, Beyrem H, Rossel M, Perrier V. Developmental exposure to the A6-pesticide causes changes in tyrosine hydroxylase gene expression, neurochemistry, and locomotors behavior in larval zebrafish. Toxicol Mech Methods. 2022, 32, 569-579.

Ramasamy P, Dakshinamoorthy G, Jayashree S, Prabhu D, Rajamanikandan S, Velusamy P, Dayanithi G, Hanna REB. A novel prototype biosensor array electrode system for detecting the bacterial pathogen Salmonella typhimurium. Biosensors (Basel) 2022, 12, 389.

Rochat C, Bernard-Marissal N, Källstig E, Pradervand S, Perrin FE, Aebischer P, Raoul C, Schneider BL. Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis. Glia. 2022, 70, 842-857.

Scheiner M, Sink A, Hoffmann M, Vrigneau C, Endres E, Carles A, Sotriffer C, Maurice T, Decker M. Photoswitchable pseudo-irreversible butyrylcholinesterase inhibitors allow optical control of inhibition in vitro and enable restoration of cognition in an Alzheimer's disease mouse model upon irradiation. J Am Chem Soc. 2022, 144, 3279-3284.

Seker Yilmaz B, Baruteau J, Arslan N, Aydin HI, Barth M, Bozaci AE, Brassier A, Canda E, Cano A, Chronopoulou E, Connolly GM, Damaj L, Dawson C, Dobbelaere D, Douillard C, Eminoglu FT, Erdol S, Ersoy M, Fang S, Feillet F, Gokcay G, Goksoy E, Gorce M, Inci A, Kadioglu B, Kardas F, Kasapkara CS, Kilic Yildirim G, Kor D, Kose M, Marelli C, Mundy H, O'Sullivan S, Ozturk Hismi B, Ramachandran R, Roubertie A, Sanlilar M, Schiff M, Sreekantam S, Stepien KM, Uzun Unal O, Yildiz Y, Zubarioglu T, Gissen P. Three-country snapshot of ornithine transcarbamylase deficiency. Life (Basel) 2022, 12, 1721.

Spatz P, Zimmermann T, Steinmuller S, Hofmann J, Maurice T, Decker M. Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model. RSC Med Chem 2022, 13, 944-954.

Zussy C, Rijo J, Urgin T, Otaegui L, Vigor C, Acar N, Canet G, Vitalis M, Morin F, Planel E, Oger C, Durand T, Rajshree SL, Givalois L, Devarajan PV, Desrumaux C. Intranasal administration of nanovectorized docosahexaenoic acid (DHA) improves cognitive function in two complementary mouse models of Alzheimer’s disease. Antioxidants 2022, 11, 838.

Abate C, Maurice T. The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0. Int J Mol Sci 2023, 24, 15868.

Baide-Mairena H, Coget A, Leboucq N, Procaccio V, Blanluet M, Meyer P, Malinge MC, François-Heude MC, Moreno M, Geneviève D, Marelli C, Roubertie A. Infantile-onset parkinsonism, dyskinesia, and developmental delay: do not forget polyglutamine defects! Ann Clin Transl Neurol 2023,10,1937-1943.

Bringuier CM, Noristani HN, Perez JC, Cardoso M, Goze-Bac C, Gerber YN, Perrin FE. Up-Regulation of Astrocytic Fgfr4 Expression in Adult Mice after Spinal Cord Injury. Cells. 2023, 12, 528.

Canet G, Zussy C, Hernandez C, Maurice T, Desrumaux C, Givalois L. The pathomimetic oAβ_25-35 model of Alzheimer's disease: Potential for screening of new therapeutic agents. Pharmacol Ther 2023, 245, 108398.

Carré C, Baudin F, Buteau B, Martine L, Grégoire S, Vasku G, Berdeaux O, Béduneau A, Pellequer Y, Jamoussi J, Desrumeaux C, Aho S, Bron AM, Acar N, Creuzot-Garcher C, Gabrielle PH. Effects of topical docosahexaenoic acid on postoperative fibrosis in an animal model of glaucoma filtration surgery. Acta Ophthalmol 2023, 101, e61-e68.

Crouzier L, Meunier J, Carles A, Morilleau A, Vrigneau C, Schmitt M, Bourguignon JJ, Delprat B, Maurice T. Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a potent sigma-1 receptor positive modulator with cognitive and neuroprotective properties. Phytother Res. 2023, in press.

Cunha P, Petit E, Coutelier M, Coarelli G, Mariotti C, Faber J, Van Gaalen J, Damasio J, Fleszar Z, Tosi M, Rocca C, De Michele G, Minnerop M, Ewenczyk C, Santorelli FM, Heinzmann A, Bird T, Amprosi M, Indelicato E, Benussi A, Charles P, Stendel C, Romano S, Scarlato M, Le Ber I, Bassi MT, Serrano M, Schmitz-Hüsch T, Doss S, Van Velzen GAJ, Thomas Q, Trabacca A, Ortigoza-Escobar JD, D'Arrigo S, Timmann D, Pantaleoni C, Martinuzzi A, Besse-Pinot E, Marsili L, Cioffi E, Nicita F, Giorgetti A, Moroni I, Romaniello R, Casali C, Ponger P, Casari G, De Bot ST, Ristori G, Blumkin L, Borroni B, Goizet C, Marelli C, Boesch S, Anheim M, Filla A, Houlden H, Bertini E, Klopstock T, Synofzik M, Riant F, Zanni G, Magri S, Di Bella D, Nanetti L, Sequeiros J, Oliveira J, Van de Warrenburg B, Schöls L, Taroni F, Brice A, Durr A. Extreme phenotypic heterogeneity in non-expansion spinocerebellar ataxias. Am J Hum Genet 2023, 110, 1098-1109.

DiFrancesco ML, Marrot M, Torre E, Mesirca P, Davaze R, Lautier C, Fontes P, Cuoq J, Fernandez A, Lamb N, Pifferi F, Mestre-Francès N, Mangoni ME, Torrente AG. Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity. Sci Rep 2023, 13, 3054.

Freyssin A, Carles A, Guehairia S, Rubinstenn G, Maurice T. Fluoroethylnormemantine (FENM) shows synergistic protection in combination with a sigma-1 receptor agonist in a mouse model of Alzheimer's disease. Neuropharmacology. 2023, 242:109733.

Grychowska K, Lopez-Sanchez U, Vitalis M, Canet G, Satała G, Olejarz-Maciej A, Gołębiowska J, Kurczab R, Pietrus W,́ Kubacka M, Moreau C, Walczak M, Blicharz-Futera K, Bantreil X, Subra G, Bojarski AJ, Lamaty F, Becamel C, Zussy C, Chaumont-Dubel S, Popik P, Nury H, Marin P, Givalois L, Zajdel P. Superiority of the triple-acting 5‑HT6R/5-HT3R antagonist and 2 MAO‑B reversible inhibitor PZ-1922 over 5‑HT6R antagonist 3 Intepirdine in alleviation of cognitive deficits in rats. J Med Chem 2023, 66, 14928-14947.

Hua J, Garcia de Paco E, Linck N, Maurice T, Desrumaux C, Manoury B, Rassendren F, Ulmann L. Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease. Cell Mol Life Sci 2023, 80, 138.

Manesco C, Saavedra-Villanueva O, Martin M, de Lizaraga J, Varga B, Cloitre T, Gerber YN, Perrin FE, Gergely C. Organization of collagen fibers and tissue hardening: Markers of fibrotic scarring after spinal cord injury in mice revealed by multiphoton-atomic force microscopy imaging. Nanomedicine 2023, 53, 102699.

Mezghrani B, Ali LMA, Cubedo N, Rossel M, Hesemann P, Durand JO, Bettache N. Periodic mesoporous ionosilica nanoparticles for dual cancer therapy: Two-photon excitation siRNA gene silencing in cells and photodynamic therapy in zebrafish embryos. Int J Pharm 2023, 641, 123083.

Perez JC, Poulen G, Cardoso M, Boukhaddaoui H, Gazard CM, Courtand G, Bertrand SS, Gerber YN, Perrin FE. CSF1R inhibition at chronic stage after spinal cord injury modulates microglia proliferation. Glia 2023 Aug 4.

Poulen G, Mercedes-Alvarez B, Rigau V, Coubes P. Bilateral periventricular nodular heterotopia and cortical dysplasia due to filamin 1 gene mutation: An invasive EEG exploration and histopathologic study. Epileptic Disord. 2023, in press.

Rachas A, Fontaine R, Thomas M, Robine JM, Gavazzi G, Laurent M, Carcaillon-Bentata L, Canouï-Poitrine F. Individual and contextual risk factors for mortality in nursing home residents during the first wave of COVID-19 in France: a multilevel analysis of a nationwide cohort study. Age Ageing 2023 52, afad165.

Richard EM, Brun E, Korchagina J, Crouzier L, Affortit C, Alves S, Cazevieille C, Mausset-Bonnefont AL, Lenoir M, Puel JL, Maurice T, Thiry M, Wang J, Delprat B. Wfs1^E864K knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential production. Cell Death Dis 2023, 14, 387.

Richard EM, Maurice T, Delprat B. Calcium signaling and genetic rare diseases: An auditory perspective. Cell Calcium 2023, 110, 102702.

Sakkaki S, Cresto N, Chancel R, Jaulmes M, Zub E, Blaquière M, Sicard P, Maurice T, Ellero-Simatos S, Gamet-Payrastre L, Marchi N, Perroy J. Dual-Hit: Glyphosate exposure at NOAEL level negatively impacts birth and glia-behavioural measures in heterozygous shank3 mutants. Environ Int. 2023, 180:108201.

Spatz P, Steinmüller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M. Dual-acting small molecules: subtype-selective cannabinoid receptor 2 agonist/butyrylcholinesterase inhibitor hybrids show neuroprotection in an Alzheimer's disease mouse model. J Med Chem 2023 66, 6414-6435.

Torres C, Garcia J, Meslé F, Barbieri M, Bonnet F, Camarda CG, Cambois E, Caporali A, Couppié E, Poniakina S, Robine JM. Identifying age- and sex-specific COVID-19 mortality trends over time in six countries. Int J Infect Dis 2023, 128, 32-40.

Trouche SG, Boutajangout A, Asuni A, Fontés P, Sigurdsson EM, Verdier JM, Mestre-Francés N. Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus). Brain Behav Immun 2023, 109, 63-77.

Vaché C, Cubedo N, Mansard L, Sarniguet J, Baux D, Faugère V, Baudoin C, Moclyn M, Touraine R, Lina-Granade G, Cossé M, Bergougnoux A, Kalatzis V, Rossel M, Roux AF. Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss. Eur J Hum Genet 2023, 31, 834-840.

Veyrunes F, Perez J, Heitzmann L, Saunders PA, Givalois L. Hormone profiles of the African pygmy mouse Mus minutoides, a species with XY female sex reversal. Effects of sex hormones and sex chromosomes on behavior. J Exp Zool Part A. 2023, in press.

Wang SM, Wu HE, Geva M, Hayden M, Maurice T, Cozzolino M, Su TP. Nucleoporin POM121 signals TFEB-mediated autophagy via activation of sigma-1 receptor by pridopidine in NSC34 model of C9ALS/FTD. Autophagy. 2023, 19, 126-151.

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