Production scientifique


Azria D, Blanquer S, Verdier JM, Belamie E (2017) Nanoparticles as contrast agents for brain nuclear magnetic resonance imaging in Alzheimer’s disease diagnosis. Journal of Materials Chemistry B (In press)

Berta T, Perrin FE, Pertin M, Tonello R, Liu YC, Chamessian A, Kato AC, Ji RR, Decosterd I (2017). Gene expression profiling of cutaneous injured and non-injured nociceptord in SNI animal model of neuropathic pain. Scientific Reports, 7:9367. DOI:10.1038/s41598-017-08865-3.

Bonneaud N, Layalle S, Colomb S, Jourdan C, Ghysen A, Severac D, Dantec C, Nègre N, Maschat F (2017) Control of nerve cord formation by Engrailed and Gooseberry-Neuro: a multi-step, coordinated process. Developmental Biology (in press)

Canet GChevallier NPerrier VDesrumaux C, Givalois L (2017).  Targeting glucocorticoid receptors: a new avenue for Alzheimer's disease therapy. In; "Pathology, Prevention and Therapeutics of Neurodegenerative Disease". Ed. Springer Nature (in press)

Charpentier MJ, Givalois L, Faurie C, Soghessa O, Simon F, Kappeler PM (2017) Seasonal variation in glucocorticoid production in mandrills depends on a suite of small-magnitude effects. American Journal of Physical Anthropology (in press).

Deckert V, Lemaire S, Ripoll PJ, de Barros JP, Labbé J, Borgne CC, Turquois V, Maquart G, Larose D, Desroche N, Ménétrier F, Le Guern N, Lebrun LJ, Desrumaux C, Gautier T, Grober J, Thomas C, Masson D, Houdebine LM, Lagrost L (2017) Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis. Scientific reports 7:3053.

Dubicanac M, Strueve J, Mestre-Francés NVerdier JM, Zimmermann E, Joly M (2017) Photoperiodic regim influences onset of lens opacities in a non-human primate. PeerJ. 5:e3258

Garnier C, Briki F, Nedelec B, Le Pogamp P, Dogan A, Rioux-Leclercq N, Goude R, Beugnet C, Martin L, Delpech M, Bridoux F, Grateau G, Doucet J, Derreumaux P, Valleix S (2017) VLITL is a major cross-β-sheet signal for fibrinogen Aα-chainframeshift variants, Blood (in press).

Garnier C, Devred F, Byrne D, Puppo R, Roman AY, Malesinski S, Golovin AV, Lebrun R, Ninkina NN, Tsvetkov PO (2017). Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates. Scientific reports 7:6812

Hirbec HE, Noristani HN, Perrin FE (2017) Microglia responses diversity in acute and chronic neurological diseases: what microglia-specific transcriptomic taught (and did not teach) us. Frontiers in Aging Neuroscience, 9:227.doi: 10.3389/fnagi.2017.00227.

Khalil B, Cabirol-Pol M-J, Miguel L, Whitworth AJ, Lecourtois M, Liévens J-C (2017). Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies. Neurobiology of Aging 54: 71–83

Khalil B, Liévens J-C (2017). Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway? Neural Regeneration Research 12: 1052-1061

Le Corre, Noristani HNMestre-Frances NSaint-Martin G, Coillot C, Goze-bac C, Lonjon NPerrin FE (2017). A novel translational model of spinal cord injury in non-human primate: multi-scale correlations fron behaviour to magnetic resonance imaging. Neurotherapeutics (in press).

Lepvrier E, Thomas D, Garnier C (2017). Hsp90 quaternary structures and the chaperone cycle: highly flexible dimeric and oligomeric structures and their regulation by co-chaperones. Current Proteomics (in press)

Louvrier J, Duchamp C, Marboutin E, Cubaynes S, Choquet R, Miquel C, Gimenez O (2017). Mapping and explaining wolf recolonization in France using dynamic occupancy models and opportunistic data. Ecography. (in press)

Noristani HN, Boukhaddaoui H, Saint-Martin GP, Auzer P, Sidiboulenouar R, Lonjon N, Alibert E, Tricaud N, Goze-Bac C, Coillot C, Perrin FE (2017). Microglial alterations after spinal cord injury: a combination of exvivo diffusion MRI and multiphoton study. Frontiers in Aging Neurosciences, 9:230. doi: 10.3389/fnagi.2017.00230.

Noristani HNGerber YN, Sabourin JC, Le Corre M, Lonjon N, Mestre-Frances N, Hirbec H and Perrin FE (2017). RNA-Seq analysis of microglia reveals time-dependent activation of specific genetic programs following spinal cord injury. Frontiers in Molecular Neuroscience, 10:90. doi: 10.3389/fnmol.2017.00090.

Perrier VImberdis TLafon P-ACefis M, Wang Y, Huetter E, Arnaud J-D, Alvarez-Martinez T, Le Guern N, Maquart G, Lagrost L, Desrumaux C (2017) Plasma cholesterol level determines in vivo prion propagation. J. Lipid Res. (in press).

Robine JMCubaynes S (2017). Worldwide demography of centenarians. Mechanisms of Ageing and Development. (in press)

Salinas S, Constant O, Desmetz C, Barthelemy J, Lemaitre JM, Millhavet O, Nagot N, Perrin FE, Saiz JC, Van de Perre P and Simonin Y (2017). Deleterious effect of Usutu virus on human neural cells. PLOS Neglected Tropical Diseases 11:e0005913

Shivappa N, Hebert JR, Kivimaki M, Akbaraly T. Alternate Healthy Eating Index 2010, Dietary Inflammatory Index and risk of mortality: results from the Whitehall II cohort study and meta-analysis of previous Dietary Inflammatory Index and mortality studies. Br J Nutr. 2017 Aug;118(3):210-221.

Virtanen M, Ferrie JE, Akbaraly T, Tabak A, Jokela M, Ebmeier KP, Singh-Manoux A, Kivimäki M. Metabolic Syndrome and Symptom Resolution in Depression: A 5-Year Follow-Up of Older Adults. J Clin Psychiatry. 2017 Jan;78(1):e1-e7.


Akbaraly TN, Kerleau C, Wyart M, Chevallier N, Ndiaye L, Shivappa N, Hébert J.R, Kivimaki M (2016). Dietary inflammatory index and recurrence of depressive symptoms: results from the Whitehall II study. Clinical Psychological Science, 4(6):1125-34.

Akbaraly TN, Tabak GT, Shipmey, MJ, Mura T, Singh-Manoux A, Ferrie J, Batty GD, Kivimaki M (2016). Little change in diet after onset of type 2 diabetes, metabolic syndrome and obesity in middle-aged adults: 11-year follow-up study. Diabetes Care 39(3):e29-30.

Ballester J, Rodó X, Robine JM, Herrmann FR (2016). European seasonal mortality and influenza incidence due to winter temperature variability. Nature Climate Change (in press)

Charroud C, Le Bars E, Deverdun J, Steffener J, Molino F, Abdennour M, Portet F, Bonafe A, Stern Y, Ritchie K, Akbaraly TN, Menjot de Champfleur N (2016). Memory Performance is related to intrinsic resting state functional connectivity changes in community-dwelling elderly cohort. Neurobiology of learning and memory 132:57-66.

Coillot C, Sidiboulenouar R, Nativel E, Zanca M, Alibert E, Saintmartin G, Noristani HN, Lonjon N, Perrin FE, Goze-Bac C (2016). Signal Modeling of a MRI Ribbon Solenoid Coil Dedicated to Spinal Cord Injuries Investigations. J. of Sensors and Sensor Systems 5, 137–145.

Deverdun J, Akbaraly TN, Charroud C, Abdennour M, Brickman AM, Chemouny S Steffener J, Portet F, Bonafe A,  Stern Y, Ritchie K,  Molino F, Le Bars E, Menjot de Champfleur N (2016). Mean arterial pressure change associated with cerebral blood flow in healthy older adults. Neurobiology of Aging 46: 49-57.

Do-Thi A, Perrin FE, Desclaux M, Saillour P, Amar L, Privat A, Mallet J (2016). Combination of grafted Schwann cells and lentiviral-prevention of glial scar formation improve recovery of spinal cord injured rats. J Chem Neuroanat 76: 48-60.

Dubicanac M, Joly M, Strüve J, Nolte I, Mestre-Francés N, Verdier JM, Zimmermann E (2016). Intraocular pressure in the smallest primate aging model: the gray mouse lemur. Veterinary Ophthalmology doi: 10.1111/vop.12434.

Fernando R, Cotter L, Perrin-Tricaud C, Berthelot J, Bartolami S, Pereira J, Gonzalez S, Suter U, Tricaud N (2016). Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nature Communications 7: 12186.

Imberdis T, Ayrolles-Torro A, Duarte, Rodrigues A, Torrent J, Alvarez Martinez MT, Kovacs GGK, Verdier JM, Robitzer M, Perrier V (2016). A fluorescent oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases. Molecular Neurodegeneration 11: 11. Highlight Inserm: 

Imberdis T, Robitzer M, Perrier V (2016). Trapping the oligomers: new promises in neurosciences. Oncotarget doi: 10.18632/oncotarget. 13800.

Labour MN, Vigier S, Lerner D, Marcilhac A, Belamie E (2016). 3D compartmented model to study the neurite-related toxicity of Aβ aggregates included in collagen gels of adaptable porosity. Acta Biomaterialia 37:38-49.

Marelli C., Maschat F (2016). P42: a novel and promising peptide-based therapy for Huntington’s disease. Orphanet Journal of Rare Diseases. 11:24. DOI: 10.1186/s13023-016-0405-3.

Maurice T (2016). Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments. Behavioural Brain Research 296: 270-278.

Maurice T, Strehaiano M, Siméon N, Bertrand C, Chatonnet A (2016) Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse. Behavioural Brain Research 296: 351-60.

Maurice T, Goguadze N (2016). Role of σ1 receptors in leaning and memory and Alzheimer's disease-type dementia. In: Sigma Receptors: Their Role in Disease and as Therapeutic Targets (Smith SB, Su TP, Eds), Springer’s Advances in Experimental Medicine and Biology series, New York.

Maurice T, Goguadze N (2016). Sigma-1 (σ1) receptors in memory and neurodegenerative diseases. In: Sigma Proteins: Molecular Pharmacology in Physiology and Pathophysiology (Kim FJ, Pasternak GW, Eds), Springer’s Handbook of Experimental Pharmacology series, New York.

Nasri A, Valverde A, Roche DB, Desrumaux C, Clair P, Beyrem H, Chaloin L, Ghysen A, Perrier V (2016). Neurotoxicity of a biopesticide analog on zebrafish larvae at nanomolar concentrations. International Journal of Molecular Sciences 17: 2137.

Noristani HNPerrin FE (2016). Astrocyte-to-neuron conversion induced by spinal cord injury. Oncotarget 7: 83831-83832.

Noristani HN, Sabourin JCC, Boukhaddaoui H, Chan-Seng E, Gerber YN, Perrin FE (2016). Spinal cord injury induces astroglial conversion towards neuronal lineage. Molecular Neurodegeneration 11: 68.

Pineau F, Canet G, Desrumaux C, Hunt H, Chevallier N, Ollivier M, Belanoff JK, Givalois L (2016). New selective glucocorticoid receptor modulators reverse amyloid-ß peptide-induced hippocampus toxicity. Neurobiology of Aging 45:109-122.

Reggiani AM, Simoni E, Caporaso R, Meunier J, Keller E, Maurice T, Minarini A, Rosini M, Cavalli A (2016). In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer’s Disease. Scientific Reports 6: 33172.

Rodríguez Cruz Y, Strehaiano M, Rodríguez Obaya T, García Rodríguez JC, Maurice T (2016). An intranasal formulation of erythropoietin (Neuro-EPO) prevents memory deficits and amyloid toxicity in the APPSwe transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease 55: 231-48.

Saunders PA, Franco T, Sottas C, Maurice T, Ganem G, Veyrunes F (2016). Masculinised Behaviour of XY Females in a Mammal with Naturally Occuring Sex Reversal. Scientif Reports 6: 22881.

Schirmer C, Lepvrier E, Duchesne L, Decaux O, Thomas D, Delamarche C, Garnier C (2016). Hsp90 directly interacs, in vitro, with amyloid structures and modulates their assembly and disassembly Biochimical Biophysical Acta General Subjects 1860: 2598-2609


Akbaraly TN, Jaussent I, Besset A, Bertrand M, Barberger-Gateau P, Ritchie K, Ferrie JE, Kivimaki M, Dauvilliers Y (2015) Sleep complaints and metabolic syndrome in an elderly population: the Three-City Study. Am J Geriatr Psychiatry 23:818-828.

Akbaraly TN, Shipley MJ, Ferrie JE, Virtanen M, Lowe G, Hamer M, Kivimaki M (2015) Long-term adherence to healthy dietary guidelines and chronic inflammation in the prospective Whitehall II study. Am J Med 128:152-160 e154.

Berger N, Van Oyen H, Cambois E, Fouweather T, Jagger C, Nusselder W, Robine JM (2015) Assessing the validity of the Global Activity Limitation Indicator in fourteen European countries. BMC Med Res Methodol 15:1.

Besson M-T, Alegría K, Garrido-Gerter P, Barros LF, Liévens J-C (2015). Enhanced neuronal glucose transporter expression reveals metabolic choice in a HD Drosophila model. PloS One 10: e0118765

Blain H, Léglise MS, Bernard PL, Dupeyron A, Pastor E, Strubel D, Akbaraly T, Abecassis F, Adnet PA, Alomène B, Amouyal M, Bardy B, Battesti MP, Baptista G, Boubakri C, Burille J, Calmels MV, Canovas G, Combe B, Delignières D, Dupeyron G, Engberink O, Gressard F, Heve D, Jakovenko D, Jeandel C, Lapierre M, Laffont I, Laurent C, Lognos B, Lussert JM, Mandrick K, Marmelat V, Martin-Gousset P, Matheron A, Mercier G, Meunier C, Morel J, Ninot G, Nouvel F, Pasdelou MP, Pélissier JY, Perrey S, Picot MC, Pinto N, Raffort N, Ramdani S, Radier-Pontal F, Royère E, Rédini-Martinez I, Robine JM, Roux E, Savy JL, Stephan Y, Tallon G, Torre K, Verdier JM, Vergotte G, Viollet E, Bedbrook A, Granier S, Camuzat T, Bourret R, Jonquet O, de la Coussaye JE, Noguès M, Aoustin M, Domy P, Bringer J, Mercier J, Bousquet J (2015). Living Lab MACVIA-LR. Equilibrium and the prevention of falls. Presse Med 44 Suppl 1: S23-30.

Bourret R, Mercier G, Mercier J, Jonquet O, De La Coussaye JE, Bousquet PJ, Robine JM, Bousquet J (2015) Comparison of two methods to report potentially avoidable hospitalizations in France in 2012: a cross-sectional study. BMC Health Serv Res 15:4.

Bousquet J, Anto JM, Berkouk K, Gergen P, Antunes JP, Auge P, Camuzat T, Bringer J, Mercier J, Best N, Bourret R, Akdis M, Arshad SH, Bedbrook A, Berr C, Bush A, Cavalli G, Charles MA, Clavel-Chapelon F, Gillman M, Gold DR, Goldberg M, Holloway JW, Iozzo P, Jacquemin S, Jeandel C, Kauffmann F, Keil T, Koppelman GH, Krauss-Etschmann S, Kuh D, Lehmann S, Carlsen KC, Maier D, Mechali M, Melen E, Moatti JP, Momas I, Nerin P, Postma DS, Ritchie K, Robine JM, Samolinski B, Siroux V, Slagboom PE, Smit HA, Sunyer J, Valenta R, Van de Perre P, Verdier JM, Vrijheid M, Wickman M, Yiallouros P, Zins M (2015) Developmental determinants in non-communicable chronic diseases and ageing. Thorax 70:595-597.

Charroud C, Steffener J, Bars EL, Deverdun J, Bonafe A, Abdennour M, Portet F, Molino F, Stern Y, Ritchie K, Champfleur NM, Akbaraly TN (2015) Working memory activation of neural networks in the elderly as a function of information processing phase and task complexity. Neurobiol Learn Mem 125: 2137-44.

Cheung SL, Yip SF, Branch LG, Robine JM (2015) Decreased Proportion of Dementia-Free Life Expectancy in Hong Kong SAR. Dement Geriatr Cogn Disord 40:72-84.

Chumakov I, Nabirotchkin S, Cholet N, Milet A, Boucard A, Toulorge D, Pereira Y, Graudens E, Traore S, Foucquier J, Guedj M, Vial E, Callizot N, Steinschneider R, Maurice T, Bertrand V, Scart-Gres C, Hajj R, Cohen D (2015) Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy. Sci Rep 5:7608.

Detrait E, Maurice T, Hanon E, Leclercq K, Lamberty Y (2015) Lack of synaptic vesicle protein SV2B protects against amyloid-beta(2)(5)(-)(3)(5)-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Behav Brain Res 271:277-285.

Ferrie JE, Kivimaki M, Akbaraly TN, Tabak A, Abell J, Davey Smith G, Virtanen M, Kumari M, Shipley MJ (2015) Change in Sleep Duration and Type 2 Diabetes: The Whitehall II Study. Diabetes Care 38:1467-1472.

Fouweather T, Gillies C, Wohland P, Van Oyen H, Nusselder W, Robine JM, Cambois E, Jagger C (2015) Comparison of socio-economic indicators explaining inequalities in Healthy Life Years at age 50 in Europe: 2005 and 2010. Eur J Public Health.

Herr M, Robine JM, Aegerter P, Arvieu JJ, Ankri J (2015) Contribution of socioeconomic position over life to frailty differences in old age: comparison of life-course models in a French sample of 2350 old people. Ann Epidemiol 25:674-680 e671.

Herr M, Robine JM, Pinot J, Arvieu JJ, Ankri J (2015) Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people. Pharmacoepidemiol Drug Saf 24:637-646.

Ikehara S, Tabak AG, Akbaraly TN, Hulman A, Kivimaki M, Forouhi NG, Iso H, Brunner EJ (2015). Age trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study. Diabetologia 58: 534-42.

Joseph-Mathurin N, Dorieux O, Trouche SG, Boutajangout A, Kraska A, Fontes PVerdier JM, Sigurdsson EM, Mestre-Frances N, Dhenain M (2015) Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds. Neurobiol Aging 34:2613-2622.

Khalil B, El Fissi N, Aouane A, Cabirol-Pol M-J, Rival T, Liévens J-C (2015). PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease. Cell Death and Disease 6: e1617

Lowe R, Ballester J, Creswick J, Robine JM, Herrmann FR, Rodo X (2015) Evaluating the performance of a climate-driven mortality model during heat waves and cold spells in Europe. Int J Environ Res Public Health 12:1279-1294.

Malik M, Rangel-Barajas C, Sumien N, Su C, Singh M, Chen Z, Huang RQ, Meunier J, Maurice T, Mach RH, Luedtke RR (2015) The Effects of Sigma-1 Receptor Selective Ligands on Muscarinic Receptor Antagonist Induced Cognitive Deficits in Mice. Br J Pharmacol (in press).

Maurice T (2015) Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments. Behav Brain Res 296:270-278.

Maurice T, Strehaiano M, Simeon N, Bertrand C, Chatonnet A (2015) Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse. Behav Brain Res (in press).

Meunier J, Borjini N, Gillis C, Villard V, Maurice T (2015) Brain toxicity and inflammation induced in vivo in mice by the amyloid-beta forty-two inducer aftin-4, a roscovitine derivative. J Alzheimers Dis 44:507-524.

Moriya T, Shibasaki R, Kayano T, Takebuchi N, Ichimura M, Kitamura N, Asano A, Hosaka YZ, Forostyak O, Verkhratsky A, Dayanithi G, Shibuya I (2015) Full-length transient receptor potential vanilloid 1 channels mediate calcium signals and possibly contribute to osmoreception in vasopressin neurones in the rat supraoptic nucleus. Cell Calcium 57:25-37.

Naert GZussy C, Tran-Van-Ba C, Chevallier N, Tang YP, Maurice TGivalois L (2015) Involvement of endogenous brain-derived neurotrophic factor in hypothalamic-pituitary-adrenal axis activity. J Neuroendocrinol 27, 850-860.

Naert GFerre V, Meunier J, Keller E, Malmstrom S, Givalois L, Carreaux F, Bazureau JP, Maurice T (2015) Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Abeta peptide administration in mice. Eur Neuropsychopharmacol 25, 2170-2182.

Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice TChevallier N, Marchal S, Takeda M, Kudo T (2015) Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death Dis 5:e1332.

Opie RS, Itsiopoulos C, Parletta N, Sanchez-Villegas A, Akbaraly TN, Ruusunen A, Jacka FN (2015) Dietary recommendations for the prevention of depression. Nutr Neurosci (in press).

Pinot J, Herr M, Robine JM, Aegerter P, Arvieu JJ, Ankri J (2015) Does the Prescription of Anxiolytic and Hypnotic Drugs Increase Mortality in Older Adults? J Am Geriatr Soc 63:1263-1265.

Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanza-Martinez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN (2015) Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2:271-274.

Sarris J, Logan AC, Akbaraly TN, Paul Amminger G, Balanza-Martinez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Parletta N, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN (2015) International Society for Nutritional Psychiatry Research consensus position statement: nutritional medicine in modern psychiatry. World Psychiatry 14:370-371.

Trousse F, Poluch S, Pierani A, Dutriaux A, Bock HH, Nagasawa T, Verdier JMRossel M (2015) CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells. Cereb Cortex 25:3446-3457.

Verdier JMAcquatella ILautier CDevau GTrouche SLasbleiz CMestre-Frances N (2015) Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases. Front Neurosci 9:64.

Virtanen M, Shipley MJ, Batty GD, Hamer M, Allan CL, Lowe GD, Ebmeier KP, Akbaraly TN, Alenius H, Haapakoski R, Singh-Manoux A, Kivimaki M (2015). Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study. Psychological medicine 45(10): 2137-44.

Yokota RT, Berger N, Nusselder WJ, Robine JM, Tafforeau J, Deboosere P, Van Oyen H (2015) Contribution of chronic diseases to the disability burden in a population 15 years and older, Belgium, 1997-2008. BMC Public Health 15:229.


Arribat Y, Talmat-Amar Y, Paucard A, Lesport P, Bonneaud N, Bauer C, Bec N, Parmentier ML, Benigno L, Larroque C, Maurel P, Maschat F (2014) Systemic delivery of P42 peptide: a new weapon to fight Huntington's disease. Acta Neuropathol Commun 2:86.

Clavier A, Baillet A, Rincheval-Arnold A, Coleno-Costes A, Lasbleiz C, Mignotte B, Guenal I (2014) The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA. Cell Death Dis 5:e1405

Detrait E, Maurice T, Hanon E, Leclercq K, Lamberty Y (2014) Lack of synaptic vesicle protein SV2B protects against amyloid-beta(2)(5)(-)(3)(5)-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Behav Brain Res 271:277-285.

Dutta A, Henley W, Robine JM, Llewellyn D, Langa KM, Wallace RB, Melzer D (2014) Aging children of long-lived parents experience slower cognitive decline. Alzheimers Dement 10:S315-322.

El Bitar F, Meunier J, Villard V, Almeras M, Krishnan K, Covey DF, Maurice T, Akwa Y (2014) Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Abeta(2)(5)(-)(3)(5) peptide-induced toxicity in vitro and in vivo in mice. Psychopharmacology (Berl) 231:3293-3312.

Filip S, Mokry J, Vavrova J, Sinkorova Z, Micuda S, Sponer P, Filipova A, Hrebikova H, Dayanithi G (2014) The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice. J Cell Mol Med 18:832-843.

Givalois L The glucocorticoid receptors regulation in Alzheimer's disease (2014) Neurobiol Aging 35:e17-18.

Graciarena M, Dambly-Chaudiere C, Ghysen A (2014) Dynamics of axonal regeneration in adult and aging zebrafish reveal the promoting effect of a first lesion. Proc Natl Acad Sci U S A 111:1610-1615.

Herr M, Arvieu JJ, Aegerter P, Robine JM, Ankri J (2014) Unmet health care needs of older people: prevalence and predictors in a French cross-sectional survey. Eur J Public Health 24:808-813.

Huc-Brandt S, Hieu N, Imberdis T, Cubedo N, Silhol M, Leighton PL, Domaschke T, Allison WT, Perrier V, Rossel M (2014) Zebrafish prion protein PrP2 controls collective migration process during lateral line sensory system development. PLoS One 9:e113331.

Imberdis T, Ayrolles-Torro A, Verdier JM, Perrier V (2014) Thienyl pyrimidine derivatives with PrP(Sc) oligomer-inducing activity are a promising tool to study prions. Curr Top Med Chem 13:2477-2483.

Lahmy V, Long R, Morin D, Villard V, Maurice T (2014) Mitochondrial protection by the mixed muscarinic/sigma1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Abeta25-35 peptide-injected mice, a nontransgenic Alzheimer's disease model. Front Cell Neurosci 8:463.

Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marchal S, Takeda M, Kudo T (2014) Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death Dis 5:e1332

Serratrice N, Cubizolle A, Ibanes S, Mestre-Frances N, Bayo-Puxan N, Creyssels S, Gennetier A, Bernex F, Verdier JM, Haskins ME, Couderc G, Malecaze F, Kalatzis V, Kremer EJ (2014) Corrective GUSB transfer to the canine mucopolysaccharidosis VII cornea using a helper-dependent canine adenovirus vector. J Control Release 181:22-31.

Viero C, Forostyak O, Sykova E, Dayanithi G (2014) Getting it right before transplantation: example of a stem cell model with regenerative potential for the CNS. Front Cell Dev Biol 2:36.


Acquatella-Tran Van Ba IImberdis TPerrier V (2013) From prion diseases to prion-like propagation mechanisms of neurodegenerative diseases. Int J Cell Biol 2013:975832.

Bertrand A, Pasquier A, Petiet A, Wiggins C, Kraska A, Joseph-Mathurin N, Aujard F, Mestre-Frances N, Dhenain M (2013) Micro-MRI study of cerebral aging: ex vivo detection of hippocampal subfield reorganization, microhemorrhages and amyloid plaques in mouse lemur primates. PLoS One 8:e56593

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Cocks G, Romanyuk N, Amemori T, Jendelova P, Forostyak O, Jeffries AR, Perfect L, Thuret S, Dayanithi G, Sykova E, Price J (2013) Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons. Stem Cell Res Ther 4:69.

Deckert V, Kretz B, Habbout A, Raghay K, Labbe J, Abello N, Desrumaux C, Gautier T, Lemaire-Ewing S, Maquart G, Le Guern N, Masson D, Steinmetz E, Lagrost L (2013) Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency. Am J Pathol 183:975-986.

Desrumaux C, Pisoni A, Meunier J, Deckert V, Athias A, Perrier V, Villard V, Lagrost L, Verdier JMMaurice T (2013) Increased amyloid-beta peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice. Neuropsychopharmacology 38:817-825.

Forostyak O, Romanyuk N, Verkhratsky A, Sykova E, Dayanithi G (2013) Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors. Stem Cells Dev 22:1506-1521.

Herr M, Arvieu JJ, Aegerter P, Robine JM, Ankri J (2013) Unmet health care needs of older people: prevalence and predictors in a French cross-sectional survey. Eur J Public Health 24:808-813.

Joseph-Mathurin N, Dorieux O, Trouche SG, Boutajangout A, Kraska A, Fontes PVerdier JM, Sigurdsson EM, Mestre-Frances N, Dhenain M (2013) Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds. Neurobiol Aging 34:2613-2622.

Lahmy V, Meunier J, Malmstrom S, Naert GGivalois L, Kim SH, Villard V, Vamvakides A, Maurice T (2013) Blockade of Tau hyperphosphorylation and Abeta(1-42) generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and sigma1 receptor agonist, in a nontransgenic mouse model of Alzheimer's disease. Neuropsychopharmacology 38:1706-1723.

Martin S, Zekri L, Metz A, Maurice T, Chebli K, Vignes M, Tazi J (2013) Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons. J Neurochem 125: 175-184.

Maurice T, Mustafa MH, Desrumaux C, Keller E, Naert G, de la C. Garcia-Barcelo M., Rodriguez Cruz Y, Garcia Rodriguez JC (2013) Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Abeta(25-35) non-transgenic mouse model of Alzheimer's disease. J Psychopharmacol 27:1044-1057.

Meunier J, Villard V, Givalois LMaurice T (2013) The gamma-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl] (2,5-difluorophenyl) amino]ethyl-5-fluorobenzen butanoic acid (BMS-299897) alleviates Abeta(1-42) seeding and short-term memory deficits in the Abeta(25-35) mouse model of Alzheimer's disease. Eur J Pharmacol 698:193-199.

Noh MY, Koh SH, Kim SM, Maurice T, Ku SK, Kim SH (2013) Neuroprotective effects of donepezil against Abeta42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3beta and nAChRs activity. J Neurochem 127:562-574.

Robine JM, Cambois E, Nusselder W, Jeune B, Oyen HV, Jagger C (2013) The joint action on healthy life years (JA: EHLEIS). Arch Public Health 71:2.

Schuster K, Ghysen A (2013) Labeling second-order sensory neurons in the posterior lateral-line system of zebrafish. Cold Spring Harb Protoc 2013:1175-1177.

Schuster K, Ghysen A (2013) Labeling hair cells and afferent neurons in the posterior lateral-line system of zebrafish. Cold Spring Harb Protoc 2013:1172-1174.

Schuster K, Ghysen A (2013) Making mosaic fish primordia by focal electroporation. Cold Spring Harb Protoc 2013:1169-1171.

Schuster K, Ghysen A (2013) Labeling defined cells or subsets of cells in zebrafish by Kaede photoconversion. Cold Spring Harb Protoc 2013.

Schuster K, Ghysen A (2013) Time-lapse analysis of primordium migration during the development of the fish lateral line. Cold Spring Harb Protoc 2013.

Zussy CBrureau AKeller EMarchal SBlayo CDelair BIxart GMaurice TGivalois L (2013) Alzheimer's Disease Related Markers, Cellular Toxicity and Behavioral Deficits Induced Six Weeks after Oligomeric Amyloid-beta Peptide Injection in Rats. PLoS One 8:e53117.

Wada H, Dambly-Chaudière C, Kawakami K, Ghysen A (2013) Innervation is required for sense organ development in the lateral line system of adult zebrafish. Proc Natl Acad Sci U S A. 110:5659-64.

Wada H, Ghysen A, Asakawa K, Abe G, Ishitani T, Kawakami K (2013) Wnt/Dkk negative feedback regulates sensory organ size in zebrafish. Curr Biol 23:1559-1565.


Acquatella-Tran Van Ba I, Marchal S, Francois F, Silhol M, Lleres C, Michel B, Benyamin Y, Verdier JM, Trousse F, Marcilhac A (2012) Regenerating islet-der ived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. J Biol Chem 287:4726-4739.

Alba R, Bradshaw AC, Mestre-Frances N, Verdier JM, Henaff D, Baker AH (2012) Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus). Gene Ther 19:109-113.

Berka K, Hendrychová T, Anzenbacherová E, Lange R, Mašek V, Anzenbacher P, Otyepka M ( 2012) Binding of Quinidine Radically Increases the Stability and Decreases the Flexibility of Cytochrome P450 2D6 Active Site. J. Inorg. Biochem. 110: 46-50.

Dayanithi G, Forostyak O, Ueta Y, Verkhratsky A, Toescu EC (2012) Segregation of calcium signalling mechanisms in magnocellular neurones and terminals. Cell Calcium 51 (3-4):293-299

Duclot F, Lapierre M, Fritsch S, White R, Parker MG, Maurice T, Cavailles V (2012) Cognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression. Genes Brain Behav 11:69-78.

Espallergues J, Mamiya T, Vallee M, Koseki T, Nabeshima T, Temsamani J, Laruelle C, Maurice T (2012) The antidepressant-like effects of the 3beta-hydroxysteroid dehydrogenase inhibitor trilostane in mice is related to changes in neuroactive steroid and monoamine levels. Neuropharmacology 62:492-502.

Galas S, Chateau MT, Pomies P, Wang J, Menardo J, Puel JL, Hugnot JP, Verdier JM, Devau G (2012) [The diversity of aging models]. Med Sci (Paris) 28:297-304.

Labour MN, Banc A, Tourrette A, Cunin F, Verdier JM, Devoisselle JM, Marcilhac A, Belamie E (2012) Thick collagen-based 3D matrices including growth factors to induce neurite outgrowth. Acta Biomater 8:3302-3312.

Languille S, Blanc S, Blin O, Canale CI, Dal-Pan A, Devau G, Dhenain M, Dorieux O, Epelbaum J, Gomez D, Hardy I, Henry PY, Irving EA, Marchal J, Mestre-Frances N, Perret M, Picq JL, Pifferi F, Rahman A, Schenker E, Terrien J, Thery M, Verdier JM, Aujard F (2012) The grey mouse lemur: a non-human primate model for ageing studies. Ageing Res Rev 11:150-162.

Lemos JR, Ortiz-Miranda SI, Cuadra, AE Velazquez-Marrero C, Custer EE, Dad T, Dayanithi G. (2012) Modulation/physiology of calcium channel sub-types in neurosecretory terminals. Cell Calcium 51 (3-4):284-292

Marchal S, Marabotti A, Staiano M, Varriale A, Domaschke T, Lange R, D'Auria S (2012) Under pressure that splits a family in two. The case of lipocalin family. PLoS One 7:e50489.

Marchal S, Givalois L, Verdier JM, Mestre-Frances N (2012) Distribution of lithostathine in the mouse lemur brain with aging and Alzheimer's-like pathology. Neurobiol Aging 33:431 e415-425.

Menardo J, Tang Y, Ladrech S, Lenoir M, Casas F, Michel C, Bourien J, Ruel J, Rebillard G, Maurice T, Puel JL, Wang J (2012) Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea. Antioxid Redox Signal 16:263-274.

Mestre-Frances N, Nicot S, Rouland S, Biacabe AG, Quadrio I, Perret-Liaudet A, Baron T, Verdier JM (2012) Oral transmission of L-type bovine spongiform encephalopathy in primate model. Emerg Infect Dis 18:142-145.

Moriya T, Kayano T, Kitamura N, Hosaka YZ, Asano A, Forostyak O, Verkhratsky A, Viero C, Dayanithi G, Toescu EC, Shibuya I. (2012) Vasopressin-induced intracellular Ca2+ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Research 1483: 1-12.

Nicot S, Bencsik A, Morignat E, Mestre-Frances N, Perret-Liaudet A, Baron T (2012) Differentiation of prions from L-type BSE versus sporadic Creutzfeldt-Jakob disease. Emerg Infect Dis 18:2028-2031.

Phillips RS, Wang AK, Marchal S, Lange R (2012) Effects of Pressure and Osmolytes on the Allosteric Equilibria of Salmonella typhimurium Tryptophan Synthase. Biochemistry 51:9354-9363.

Robine JM, Michel JP, Herrmann FR (2012) Excess male mortality and age-specific mortality trajectories under different mortality conditions: a lesson from the heat wave of summer 2003. Mech Ageing Dev 133:378-386.

Toescu EC, Dayanithi G (2012) Neuroendocrine signaling: Natural variations on a Ca2+ theme. Cell Calcium 51 (3-4):207-211.

Torrent J, Lange R (2012) High pressure, a tool to switch between soluble and fibrillar prion protein structures. Commun Integ Biol 5:130-33.


Abraham JD, Calvayrac-Pawlowski S, Cobo S, Salvetat N, Vicat G, Molina L, Touchon J, Michel BF, Molina F, Verdier JM, Fareh J, Mourton-Gilles C (2011) Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between Alzheimer's disease and other dementias. Biomarkers 16:161-171.

Ayrolles-Torro A, Imberdis T, Torrent J, Toupet K, Baskakov IV, Poncet-Montange G, Gregoire C, Roquet-Baneres F, Lehmann S, Rognan D, Pugniere M, Verdier JM, Perrier V (2011) Oligomeric-Induced Activity by Thienyl Pyrimidine Compounds Traps Prion Infectivity. J Neurosci 31:14882-14892.

Chevallier N, Keller E, Maurice T (2011) Behavioural phenotyping of knockout mice for the sigma-1 (sigma) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations. J Psychopharmacol 25:960-975.

El Moustaine D, Perrier V, Acquatella-Tran Van Ba I, Meersman F, Ostapchenko VG, Baskakov IV, Lange R, Torrent J (2011) Amyloid features and neuronal toxicity of mature prion fibrils are highly sensitive to high pressure. J Biol Chem 286:13448-13459.

Espallergues J, Temsamani J, Laruelle C, Urani A, Maurice T (2011) The antidepressant-like effect of the 3beta-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of beta-type estrogen receptors. Psychopharmacology (Berl) 214:455-463.

Hendrychova T, Anzenbacherova E, Hudecek J, Skopalik J, Lange R, Hildebrandt P, Otyepka M, Anzenbacher P (2011) Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations. Biochim Biophys Acta 1814:58-68.

Kraska A, Dorieux O, Picq JL, Petit F, Bourrin E, Chenu E, Volk A, Perret M, Hantraye P, Mestre-Frances N, Aujard F, Dhenain M (2011) Age-associated cerebral atrophy in mouse lemur Primates. Neurobiol Aging 32(5):894-906.

Naert G, Ixart G, Maurice T, Tapia-Arancibia L, Givalois L (2011) Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Mol Cell Neurosci 46:55-66.

Torrent J, Lange R High pressure, a tool to switch between soluble and fibrillar prion protein structures (2011) Commun Integr Biol 5:30-33.

Villard V, Meunier J, Chevallier N, Maurice T (2011) Pharmacological Interaction With the Sigma(1) (sigma(1))-Receptor in the Acute Behavioral Effects of Antidepressants. J Pharmacol Sci 115:279-292.

Zussy C, Brureau A, Delair B, Marchal S, Keller E, Ixart G, Naert G, Meunier J, Chevallier N, Maurice T, Givalois L (2011) Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid beta fragment in rats. Am J Pathol 179:315-334.