Habilitation à Diriger des Recherches
Assistant Professor at the University of Montpellier, France
Phone: 04 67 14 48 30
Team 1: Cerebral aging and neurodegenerative diseases
I carry my teaching and my research in the field of Neurosciences at the Faculty of Science of the University of Montpellier. I am responsible for several Teaching Units in Bachelor and Master. I am interested by the regulatory processes. During my thesis, I have analyzed the effect of serotonin on tyrosine hydroxylase activity of locus coeruleus neurons in culture. Then, in the laboratory Inserm U254 and Inserm 432, I have studied the glutamatergic synaptic transmission in the vestibular and cochlear sensory systems. I have investigated the changes in intracellular calcium induced by activation of glutamate receptors and transporters. Finally, in the MMDN laboratory, Inserm U710 and Inserm 1198, I have explored the gene expression changes during healthy aging and neurodegenerative diseases such as Alzheimer’s disease using transcrptomic approaches, Affymetrix microarrays and RNA-seq. Specific transcriptomic profiles were revealed in relation with age or with the pathology. Some genes were detected highly discriminant to differentiate cerebral aging and the pathology. These studies were funded by the Région Languedoc-Roussillon et interministériel funds "DiaTrAl", National Plan Alzheimer “PRANET“, Européen FP7 "BrainCAV" . I have participated in several meetings organized by Boris Cyrulnik and Antoine Lejeune about resilience process occurring in pathologies associated to aging. I am also implicated to increase public awareness of the progress and benefits of brain research to a large audience. I am in charge on the organization of the Brain Awareness Week in Montpellier, every March. With a local committee, we have created the neurosciences association "La comédie des Neurones".